Here, We Luckier in Love Everyday". Introducing you a Lakshmi 2025 Edition. Amidst the buzz of the mall, take charge of your love destiny—because fate is so last season.
พระแม่ลักษมี เทพีเเห่งความเจริญรุ่งเรืองในศาสนาฮินดู โดยนอกจากจะเป็นเทพีเเห่งความรุ่งเรืองแล้ว ในไทยยังนับถือพระแม่ในฐานะเทพเจ้าเเห่งความรักจนเกิดปรากฏการรณ์ I Told พระแม่ หรือ I Told Lakshmi จากเหตุผลดังกล่าว จึงนำมาสู่การประยุกษ์ใช้ลักษณะดังกล่าวมาออกแบบ และผลิตเป็นเครื่องทำนายโชคชะตาเพื่อเสริมสร้างความพึงพอใจของลูกค้า รวมไปถึงการสร้างพฤติกรรมผู้บริโภคของลุกค้า
คณะวิศวกรรมศาสตร์
Nowadays, consumers may have experienced situations where they don't know which product to use based on their skin problems, the product they use doesn't give the desired results, the product is not worth the price, allergic to certain chemicals in the product ,or use multiple products and have ingredients that should not be used together leading to irritation. For this reason, we develop an application to analyze skin care product ingredients to solve such problems. This allows consumers to correctly understand information about the ingredients in products and know which products they should use according to their skin problems without having to rely on chemical knowledge and get products that are the best value for money. The project has integrated software knowledge to develop an application for analyzing skin care product ingredients. To find and recommend suitable skin care products to consumers. The information on various important ingredients has been collected from reliable articles and research.
คณะแพทยศาสตร์
Background: The RGL3 gene plays a role in key signal transduction pathways and has been implicated in hypertension risk through the identification of a copy number variant deletion in exon 6. Genome-wide association studies have highlighted RGL3 as associated with hypertension, providing insights into the genetic underpinnings of the condition and its protective effects on cardiovascular health. Despite these findings, there is a lack of data that confirms the precise role of RGL3 in hypertension. Additionally, the functional impact of certain variants, particularly those classified as variants of uncertain significance, remains poorly understood. Objectives: This study aims to analyze alterations in the RGL3 protein structure caused by mutations and validate the location of the ligand binding sites. Methods: Clinical variants of the RGL3 gene were obtained from NCBI ClinVar. Variants of uncertain significance and likely benign were analyzed. Multiple sequence alignment was conducted using BioEdit v7.7.1. AlphaFold 2 predicted the wild-type and mutant 3D structures, followed by quality assessment via PROCHECK. Functional domain analysis of RasGEF, RASGEF_NTER, and RA domains was performed, and BIOVIA Discovery Studio Visualizer 2024 was used to evaluate structural and physicochemical changes. Results: The analysis of 81 RGL3 variants identified 5 likely benign and 76 variants of uncertain significance (VUS), all of which were missense mutations. Structural modeling using AlphaFold 2 revealed three key domains: RasGEF_NTER, RasGEF, and RA, where mutations induced conformational changes. Ramachandran plot validation confirmed 79.7% of residues in favored regions, indicating an overall reliable structure. Moreover, mutations within RasGEF and RA domains altered polarity, charge, and stability, suggesting potential functional disruptions. These findings provide insight into the structural consequences of RGL3 mutations, contributing to further functional assessments. Discussion & Conclusion: The identified RGL3 mutations induced physicochemical alterations in key domains, affecting charge, polarity, hydrophobicity, and flexibility. These changes likely disrupt interactions with Ras-like GTPases, impairing GDP-GTP exchange and cellular signaling. Structural analysis highlighted mutations in RasGEF and RA domains that may interfere with activation states, potentially affecting protein function and stability. These findings suggest that mutations in RGL3 could have functional consequences, emphasizing the need for further molecular and functional studies to explore their pathogenic potential.
คณะอุตสาหกรรมอาหาร
This research aims to optimize the production process of gamma-aminobutyric acid (GABA) in fermented pineapple juice using probiotics and acetic acid bacteria (AAB), which are microorganisms with the potential to enhance GABA levels. This process has been developed to improve the nutritional value of fermented pineapple juice and to increase the economic value of Thai pineapples, which have long suffered from low market prices. This study focuses on determining the optimal conditions for GABA production by examining factors such as sugar content, pH levels, fermentation duration, and L-glutamate concentration, as well as the co-cultivation of probiotics and acetic acid bacteria. The experiments are conducted using controlled fermentation techniques, and the bioactive components of the fermented juice are analyzed with advanced instruments such as HPLC and GC-MS. The findings of this research are expected to contribute to the development of formulations and production processes for a high-GABA pineapple-based functional beverage. This product could offer health benefits such as stress reduction, cognitive function enhancement, and relaxation while also strengthening the potential of Thailand’s fermented food and beverage industry.