The design site of 22 hectares of agricultural land in this area is located in Tatata District, Iglenburg Province. The design concept of this area aims to encourage farmers and communities to earn income from the agricultural products produced in this area, and emphasizes that this area is a "living market", which can not only create food from a variety of crops, but also establish a balanced ecosystem and promote biodiversity in this area. The market will become a sustainable market area, which is not only beneficial to society in promoting economy, but also beneficial to the environment. The area will serve as a social and learning center, where community members can fully exchange agricultural information and experience and stimulate the economy in the community in another way.
เพื่อศึกษาการออกแบบภูมิทัศน์
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.
คณะเทคโนโลยีสารสนเทศ
The project of game development to educate about Egyptian civilization This is intended to be a game to promote learning about ancient Egyptian civilization. The original learning may feel boring. Do not attract the attention of learners Therefore saw the presentation in the form of a game on virtual reality technology that inserts knowledge history With the aim of making learning more interesting The organizers can choose to use Unreal Engine 5.1 (Unreal Engine 5.1) and Oculus Quest II (Oculus Quest2) to develop. Within the game, players must find a way to escape from this room within the specified period of solving puzzles in various forms such as statues, traps, etc. In order to solve puzzles and leave this room, players must collect all the information inside the room. In addition, the game shows the life of the player and when the player cannot solve the puzzle correctly.
คณะวิศวกรรมศาสตร์
In Thailand, the quantity of old tires has been increasing annually, posing a significant environmental challenge due to their non-biodegradable material. However, old tires contain an internal porous structure, which suggests their potential application as sound-absorbing materials. Porosity is a key characteristic that enables materials to trap sound waves, making them effective for noise reduction. Therefore, this study aims to investigate and develop sound-absorbing materials from old tire rubber powder. The methodology involved mixing old tire powder with fresh latex at a ratio of 1:2, followed by drying at a temperature of 120°C for four hours. Subsequently, the physical properties influencing sound absorption, including density, porosity, and water absorption, were analyzed. The results indicated that the sound-absorbing material produced from old tire rubber powder showed a density of 0.96 g/cm³, a porosity value of 0.45, and a water absorption of 11.03%. Therefore, the findings suggest that old tire rubber powder has the potential to be effectively utilized as a sound-absorbing material.