This research presents a Digital Twin of an Aquarium for Water Quality Monitoring, developing a virtual model that displays real-time key water parameters, including pH level, temperature, flow rate, and dissolved oxygen. Sensor data is processed and visualized through a Graphical User Interface (GUI) to reflect the real-time status of the virtual aquarium. This system enables accurate water quality monitoring and analysis while reducing reliance on expensive software solutions.
มีเป้าหมายในการสร้าง Digital Twin ของตู้ปลา เพื่อใช้เป็นกรณีศึกษาในการตรวจสอบคุณภาพน้ำ โดยนำเซ็นเซอร์ตรวจวัด ค่าความเป็นกรด-ด่าง (pH), อุณหภูมิ, อัตราการไหลของน้ำ และออกซิเจนละลายน้ำ มาประมวลผลและแสดงผลผ่านอินเทอร์เฟซกราฟิกแบบเรียลไทม์ ระบบนี้สามารถใช้เป็นสื่อการสอนด้าน คอมพิวเตอร์ช่วยงานเทคโนโลยีการผลิต โดยไม่ต้องพึ่งพาซอฟต์แวร์ราคาแพง ซึ่งช่วยลดต้นทุนและเพิ่มโอกาสในการศึกษา Digital Twin อย่างมีประสิทธิภาพ
คณะวิทยาศาสตร์
Photocatalytic materials decorated with bi-metallic nanoparticles (Bi-Metallic NPs/ photocatalyst) was synthesized for the degradation of aflatoxin B1. Bi-metallic NPs/ photocatalyst were synthesized by ultrasonic irradiation. The as-synthesized was characterized the chemical characteristics by the transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction analysis (XRD), Fourier transform infrared spectrometer (FT-IR), zeta potential analyzer, and UV-visible spectrophotometer. Bi-metallic NPs/photocatalyst was used to evaluate the degradation efficiency of AFB1 in household wastewater under visible light. The degradation process was analyzed using high-performance liquid chromatography (HPLC) at a wavelength of 365 nm, revealing that AFB1 was completely degraded 100% within 2 minutes. This superior performance is attributed to its highly porous structure, increased specific surface area, and reduced electron-hole recombination rate, which demonstrate that the developed nanomaterial has successfully achieved AFB1 degradation.
คณะวิทยาศาสตร์
The development of a fruit spoilage detection system originates from the need to reduce agricultural product losses, a global issue affecting both the agricultural and food distribution industries. Spoiled fruit can negatively impact product quality and result in significant economic losses. The primary goal of this system is to assist in screening and removing unsuitable fruit from the supply chain, thereby preserving product quality and meeting consumer demands for fresh produce. The system was designed to simulate the sorting process by utilizing images as a key factor in detecting spoiled fruit. Experimental results demonstrated high efficiency and rapid prediction capabilities, highlighting the system’s potential for practical applications.
คณะวิทยาศาสตร์
Cancer remains a major global health challenge as the second-leading cause of human death worldwide. The traditional treatments for cancer beyond surgical resection include radiation and chemotherapy; however, these therapies can cause serious adverse side effects due to their high killing potency but low tumor selectivity. The FDA approved monoclonal antibodies (mAbs) that target TIGIT/PVR (T-cell immunoglobulin and ITIM domain/poliovirus receptor) which is an emerging immune checkpoint molecules has been developed; however, the clinical translation of immune checkpoint inhibitors based on antibodies is hampered due to immunogenicity, immunological-related side effects, and high costs, even though these mAbs show promising therapeutic efficacy in clinical trials. To overcome these bottlenecks, small-molecule inhibitors may offer advantages such as better oral bioavailability and tumor penetration compared to mAbs due to their smaller size. Here, we performed structure-based virtual screening of FDA-approved drug repertoires. The 100 screened candidates were further narrowed down to 10 compounds using molecular docking, with binding affinities ranging from -9.152 to -7.643 kcal/mol. These compounds were subsequently evaluated for their pharmacokinetic properties using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, which demonstrated favorable drug-like characteristics. The lead compounds will be further analyzed for conformational changes and binding stability against TIGIT through molecular dynamics (MD) simulations to ensure that no significant conformational changes occur in the protein structure. Collectively, this study represents the potential of computational methods and drug repurposing as effective strategies for drug discovery, facilitating the accelerated development of novel cancer treatments.