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คณะพยาบาลศาสตร์
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คณะวิทยาศาสตร์
This study aimed to develop an anti-acne gel formulation using partially purified Limnophila aromatica extract and to evaluate its antibacterial efficacy, stability, and safety in accordance with international standards. The raw material was extracted using 99.9% v/v ethanol and partially purified via ion-exchange resin column chromatography. The resulting extract was formulated into a Carbopol 940 base gel at varying concentrations. The results demonstrated that the extract exhibited potent inhibitory and bactericidal activities against Cutibacterium acnes (MIC/MBC = 14.26 µg/mL), performing twice as effectively as Centella asiatica extract and comparably to Garcinia mangostana peel extract. In formulation testing, the L. aromatica acne gel selectively inhibited C. acnes without disrupting the normal skin microbiota, Staphylococcus epidermidis. Accelerated stability testing (at 40 °C and 50 °C for 3 months) revealed excellent formulation stability, with no phase separation or precipitation and a stable pH of 5.9–6.1, indicating a shelf life of 1 year. Regarding safety, the product met international standards (FDA BAM (2024), ISO 22717:2015, ISO 22718: 2015, USP 46/NF41:2023 และ USP 44), showed no cytotoxicity toward human HaCaT keratinocytes (IC50 > 1000 µg/mL), and induced no skin irritation in a human volunteer panel of 30 subjects (Mean Irritation Index = 0.00). In conclusion, the L. aromatica acne gel demonstrates an optimal balance of efficacy, stability, and safety. Free from parabens, silicones, and synthetic fragrances, this formulation is fully prepared for technology transfer and commercialization in the cosmeceutical industry.
คณะสถาปัตยกรรม ศิลปะและการออกแบบ
Rapid global urbanization has led to a continuous rise in urban populations, posing critical challenges to spatial and resource allocation in modern cities. This project aims to synthesize core urban planning issues into balanced scenarios and develop a prototype titled "Block Game: Learning of Spatial Urban Resource Management." Serving as an interactive learning tool, the game transforms complex theoretical concepts into tangible hands-on experiences. Designed for both urban planning students and the general public, the game allows players to step into the shoes of urban planners—experimenting with spatial layouts, balancing population capacity with available land, and reserving space for future development. Through experiential learning, collaborative decision-making, active listening, and iterative design reflection, this prototype simplifies intricate academic principles into an engaging format. Ultimately, it fosters foundational spatial reasoning and participatory skills necessary for addressing future urban complexities, such as disaster risk management and climate change adaptation.